Fig. 6: Effects of MT on hippocampal Cathepsin B expression, NLRP3 inflammasome activation and pyroptosis in CRS rats. | Translational Psychiatry

Fig. 6: Effects of MT on hippocampal Cathepsin B expression, NLRP3 inflammasome activation and pyroptosis in CRS rats.

From: Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats

Fig. 6

A The relative protein expression of Cathepsin B, NLRP3, ASC, Cleaved caspase-1, GSDMD-N, IL-1β, and IL-18. B–H Proteins quantitative analysis of Cathepsin B, NLRP3, ASC, Cleaved caspase-1, GSDMD-N, IL-1β, and IL-18. I Representative Iba-1, NLRP3, and Cleaved caspase-1 triple-labeled immunofluorescent images in the hippocampus, 400× magnification; scale bars = 20 µm. All data are presented as the mean ± SD (n = 6). *P < 0.05 and **P < 0.01 versus CON group. #P < 0.05 and ##P < 0.01 versus CRS group. &P < 0.05 and &&P < 0.01 versus ALC + CRS group.

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