Fig. 8: Effects of nitroxoline and MCC950 on hippocampal NLRP3 inflammasome activation and pyroptosis in CRS rats. | Translational Psychiatry

Fig. 8: Effects of nitroxoline and MCC950 on hippocampal NLRP3 inflammasome activation and pyroptosis in CRS rats.

From: Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats

Fig. 8

A, H The relative protein expression of NLRP3, ASC, Cleaved caspase-1, GSDMD-N, IL-1β, and IL-18. B Proteins quantitative analysis of NLRP3. C, I Proteins quantitative analysis of ASC. D, J Proteins quantitative analysis of Cleaved caspase-1. E, K Proteins quantitative analysis of GSDMD-N. F, L Proteins quantitative analysis of IL-1β. G, M Proteins quantitative analysis of IL-18. All data are presented as the mean ± SD (n = 6). **P < 0.01 versus N + CRS or M + CRS group.

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