Fig. 9: Effects of MT on hippocampal Cathepsin B expression, NLRP3 inflammasome activation and pyroptosis in rats induced by Pazopanib. | Translational Psychiatry

Fig. 9: Effects of MT on hippocampal Cathepsin B expression, NLRP3 inflammasome activation and pyroptosis in rats induced by Pazopanib.

From: Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats

Fig. 9

A The relative protein expression of Cathepsin B, NLRP3, ASC, Cleaved caspase-1, GSDMD-N, IL-1β, and IL-18. B–H Proteins quantitative analysis of Cathepsin B, NLRP3, ASC, Cleaved caspase-1, GSDMD-N, IL-1β, and IL-18. All data are presented as the mean ± SD (n = 6).*P < 0.05 and **P < 0.01 versus P + CON group. ##P < 0.01 versus Pazopanib group. &P < 0.05 versus ALC + Pazopanib group.

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