Table 4 Association (beta[p]) of schizophrenia polygenic risk score for each Complement gene located in the MHC region separately with axonal density in association tracts.

From: Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure

 

n SNPs

CG

iFO

sL

Unc

Added risk

 

−0.019 (0.0003)

−0.028 (2*10−7)

−0.027 (7*10−7)

−0.023 (1*10−5)

C2

2

−0.024 (1*10−5)

−0.033 (5*10−10)

−0.030 (2*10−8)

−0.025 (3*10−6)

C4A

1

−0.001 (0.92)

−0.006 (0.24)

−0.002 (0.70)

−0.005 (0.36)

C4B

3

−0.022 (4*10−5)

−0.032 (2*10−9)

−0.030 (2*10−8)

−0.024 (8*10−6)

CFB

2

−0.020 (0.0001)

−0.031 (4*10−9)

−0.028 (1*10−7)

−0.024 (1*10−5)

  1. n SNPs number of SNPs included in the PRS after clumping.
  2. CG Cingulum-cingulate gyrus part, iFO Inferior fronto-occipital fasciculus, sL Superior longitudinal fasciculus, Unc Uncinate fasciculus.
  3. Bonferroni corrected (20 tests) significant results are highlighted in bold.