Fig. 1: PEL-induced cognitive dysfunction. | Translational Psychiatry

Fig. 1: PEL-induced cognitive dysfunction.

From: Oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal ERK signaling and Aβ deposition

Fig. 1

A Trajectories of PEL mice (n = 6) and Sham mice (n = 6) in the MWM place navigation experiment. B Quantitative analysis of latency in the MWM place navigation experiment. (F (1, 46) = 50.95, p < 0.01.). C Trajectories of PEL (n = 6) mice and Sham (n = 6) mice in the MWM spatial exploration experiment. The shaded part is the area around the platform, and the activity time of mice in the shaded part is calculated. D Quantitative analysis of swimming time around the platform in the MWM spatial exploration experiment. (t = 2.245, df = 10, p < 0.05.). E Trajectories of PEL (n = 6) and Sham (n = 6) mice in the three-chambers social experiment (S1), The shaded area is the cage where S1 is located. F Quantification of the social index of S1. (t = 3.012, df = 10, p < 0.05). G Trajectory of PEL (n = 6) and Sham (n = 6) mice in the three-chambers social experiment (S2), The shaded area is the cage where S2 is located. H Quantification results of S2 social index. (t = 3.666, df = 10, p < 0.05.). Data are analyzed by 2-way ANOVA (B) and unpaired t test (D, F, H). data are expressed as mean ± SEM. Compared with Sham, *P < 0.05, **P < 0.01. MWM Morris Water Maze, S1 Stranger1, S2 Stranger2.

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