Fig. 3: Exogenous supplementation of OXT attenuated hypothalamic-derived cognitive dysfunction.

A Trajectories of PEL-treated group (n = 6), AVP-supplemented group (n = 6), OXT-supplemented group (n = 6), and ATO group (n = 6) in the MWM place navigation experiment. B Quantitative analysis of latency in the MWM place navigation experiment. (F (3, 92) = 23.80 p < 0.01). C Trajectories of PEL-treated group (n = 6), AVP-supplemented group (n = 6), OXT-supplemented group (n = 6), and ATO group (n = 6) in the MWM spatial exploration experiment. The shaded part is the area around the platform, and the activity time of mice in the shaded part is calculated. D Quantitative analysis of swimming time around the platform in the MWM spatial exploration experiment. (F (3, 20) = 10.56, p < 0.01). E Trajectories diagrams of PEL-treated group (n = 6), AVP-supplemented group (n = 6), OXT-supplemented group (n = 6), and ATO group (n = 6) in the three-chambers social experiment (S1). The shaded area is the cage where S1 is located. F Quantitative results of S1 social index. (F (3, 20) = 1.054, p = 0.3908). G Trajectories of PEL-treated group (n = 6), AVP-supplemented group (n = 6), OXT-supplemented group (n = 6), and ATO group (n = 6) in the three-chambers social experiment (S2). The shaded area is the cage where S2 is located. H Quantification results of S2 social index. F (3.000, 10.13) = 6.611, p < 0.01. Data were analyzed by two-way ANOVA (B), 1-way ANOVA followed by LSD multiple comparisons test (D, F) and Brown-Forsythe ANOVA test (H). Data are expressed as mean ± SEM. Compared to PEL-treated group, **P < 0.01. MWM Morris Water Maze, S1 Stranger1, S2 Stranger2, OXT oxytocin, ATO Atosiban.