Fig. 1: Study flowchart of the causal relationships between structural and diffusion IDPs and the risk of major neurodegenerative diseases by using bidirectional TSMR analysis methods. | Translational Psychiatry

Fig. 1: Study flowchart of the causal relationships between structural and diffusion IDPs and the risk of major neurodegenerative diseases by using bidirectional TSMR analysis methods.

From: Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of major neurodegenerative diseases

Fig. 1

AD Alzheimer’s disease, ALS amyotrophic lateral sclerosis, CT cortical thickness, FA fractional anisotropy, FTD frontotemporal dementia, GMV gray matter volume, HD Huntington’s disease, IDPs imaging-derived phenotypes, IVW inverse-variance weighted, LBD Lewy body dementia, MD mean diffusivity, ML maximum likelihood, MS multiple sclerosis, PD Parkinson’s disease, RAPS MR-robust adjusted profile scores, SA surface area, TSMR two-sample Mendelian randomization, WM weighted median.

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