Fig. 3: The results of reverse MR analyses (neurodegenerative diseases as exposures and brain IDPs as outcomes). | Translational Psychiatry

Fig. 3: The results of reverse MR analyses (neurodegenerative diseases as exposures and brain IDPs as outcomes).

From: Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of major neurodegenerative diseases

Fig. 3

A Circos plot shows all the results. The x-axis shows each IDP and the y-axis shows -log10(P) values. The results of FTD are present in the Wald ratio method and the results of other diseases are present in the IVW method. The outer and inner gray lines represent P = 2.64 × 10−5 and P = 1.00 × 10−4, respectively. B Pattern diagram shows the brain locations of the significant and nominal results of the causal effects of brain IDPs on AD, LBD, and FTD. C Forest plot shows significant and nominally significant results of the causal effects of AD, LBD, and FTD on brain IDPs in the IVW or Wald ratio method. The x-axis shows causal effects and 95% CI. Please refer to Fig. 1 legends for all the abbreviations.

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