Table 2 Comparison of neurotrophic factors and oxidative stress parameters with the healthy control and patient groups (Control: Healthy Control & Patient: pre-rTMS).

From: Altered blood parameters in “major depression” patients receiving repetitive transcranial magnetic stimulation (rTMS) therapy: a randomized case-control study

Variables

 

Control (n = 25)

Patient (n = 26)

p

BDNF ng/mL

mean ± SD

8.02 ± 1.11

3.68 ± 0.9

<0.01*a

S100B ng/L

100.76 ± 20.25

194.8 ± 22.47

<0.01*a

ALLO pg/mL

1195.26 ± 158.42

694.34 ± 81.54

<0.01*a

TAS mmol ascorbate Eq./L

0.99 ± 0.12

0.72 ± 0.11

<0.01*a

OSI AU

10.79 ± 3.01

20.5 ± 5.01

<0.01*a

NT μM

422.68 ± 46.72

275.13 ± 78.5

<0.01*a

DIS μM

51.68 ± 33.32

79.89 ± 43.19

<0.01*a

GDNF pg/mL

mean (min-max)

416.01 (385.75–618.91)

217.08 (154.75–250.03)

<0.01*b

TOS μmol H2O2 Eq./L

10.08 (6.8–16.53)

14.68 (10.43–18.48)

<0.01*b

TT μM

516.62 (446.21–635.02)

429.17 (371.24–582.69)

<0.01*b

  1. BDNF Brain-Derived Neurotrophic Factor, S100B S100 calcium-binding protein B, ALLO Allopregnanolone, TAS Total Antioxidant Status, OSI Oxidative Stress Index, NT Native Thiol, DIS Disulfide, GDNF Glial Cell Line-Derived Neurotrophic Factor, TOS Total Oxidant Status, TT Total Thiol.
  2. aIndependent Samples T-test.
  3. bMann–Whitney U test (*p < 0.01 alongside of patient).