Fig. 2: Age Moderation of Group Differences in Resting rCBF (Covarying for wbCBF). | Translational Psychiatry

Fig. 2: Age Moderation of Group Differences in Resting rCBF (Covarying for wbCBF).

From: A multi-site 99mTc-HMPAO SPECT study of cerebral blood flow in a community sample of patients with major depression

Fig. 2

A tests the age*group interaction in Newport-only participants, and E tests the interaction in depressed patients across all 8 sites (and healthy controls scanned at the Newport site). B and D show significant age effects in depressed patients from Newport or all sites, respectively, and C shows age effects in healthy controls, with warm colors representing increasing rCBF with age relative to wbCBF, and cool colors representing increases in rCBF with age that are less than the increases in wbCBF with age (see Supplementary Fig. 2A). All analyses included the main effects of age and sex, and they covaried for wbCBF. Analyses for all sites also controlled for site with seven dummy variables. Voxels with an FDR-corrected P < 0.05 were color-coded as shown in the color bar. Number of participants and abbreviations are as in Fig. 1.

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