Fig. 4: MDD severity relates to intracortical myelin concentrations in lOFC. | Translational Psychiatry

Fig. 4: MDD severity relates to intracortical myelin concentrations in lOFC.

From: Quantitative MRI at 7-Tesla reveals novel frontocortical myeloarchitecture anomalies in major depressive disorder

Fig. 4

MDD severity (IDS score) relates to increases in lOFC average T1 (inverse proxy for myelin concentration, panel B), T1 AUC (distribution of T1 across 10 cortical depths, panel C), and T1 offset (WM/GM transitional zone, panel D). Correlations (Kendall’s τ) and associated p-values for total IDS score in relation to T1-profile metrics within the lOFC are shown in red boxes. Panel A depicts the lOFC region of interest. lOFC lateral orbitofrontal cortex, WM white matter, GM gray matter, IDS inventory of depressive symptomatology.

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