Fig. 1: Multifactorial structure of the neurofunctional domains of the Addictions Neuroclinical Assessment.

Latent structure of the (A) Incentive Salience, (B) Negative Emotionality, and (C) Executive Function domains. Values above double-headed arrows indicate correlation coefficients between factors. NEO Agreeableness loaded negatively to Externalizing. TMT Combined Trail Time was negatively loaded to Working Memory. ¹ ADS #18 = Do you almost constantly think about drinking alcohol?. ² OCDS #1 = How much of your time when you’re not drinking is occupied by ideas, thoughts, impulses, or images related to drinking?. ³ OCDS #11 = If you were prevented from drinking alcohol when you desired a drink, how anxious or upset would you become?. ⁴ OCDS #13 = How strong is the drive to consume alcoholic beverages?. ADS Alcohol Dependence Scale, OCDS Obsessive Compulsive Drinking Scale, STAIT State-Trait Anxiety Inventory, Trait version, MADRS Montgomery-Åsberg Depression Rating Scale, PACS Penn Alcohol Craving Scale, SRE Self-Reported Effects of Alcohol Questionnaire, HPT Hypothetical Purchase Task, BPAQ Buss-Perry Aggression Questionnaire, CDRS Connor-Davidson Resiliency Scale, TAS20 Toronto Alexithymia Scale, PANAS Positive and Negative Affect Scale, TMT Trail Making Test, CPT Continuous Performance Task, MAIA Multidimensional Assessment of Interoceptive Awareness, MCQ Metacognition Questionnaire, BIS Barratt Impulsivity Scale, UPPS-P UPPS-P Impulsive Behavior Scale.