Fig. 4: Excess capacity, coupling eficiency, and transcript expression of uncoupling proteins (UCP)s and antioxidant enzymes superoxide dismutase (SODs) in PFC and AMY from POL-exposed and control male and female offspring.
From: Prenatal immune activation in mice induces long-term alterations in brain mitochondrial function
a Excess ETC in the PFC. A significantly higher excess ETC is observed in control males than in control females and POL-exposed mice. Multiple comparisons: ****P < 0.0001 and ***P = 0.0002. b Coupling efficiency in the PFC. A reduction in coupling efficiency is observed in POL-exposed males. Multiple comparisons: *P = 0.03. c Transcript expression analysis of the uncoupling proteins 4 (UCP4) and 5 (UCP5) in the PFC with significantly less transcripts in the POL-exposed offspring. Multiple comparisons: UCP4 *P = 0.026, and UPC5 **P = 0.0066. d Transcript expression analysis of the antioxidant enzymes superoxide dismutase 1 (SOD1) and 2 (SOD2) in the PFC with significantly higher SOD1 expression in control females than in control males and POL-exposed offspring. Multiple comparisons: *P = 0.049, **P = 0.0058. e Excess ETC in the AMY. No significant differences in excess ETC are detected across experimental groups. f Coupling efficiency in the AMY. No alterations were observed. g Transcript expression analysis of UCPs in the AMY. POL-exposed male and female offspring mice show an apparent (but non-statistically significant) reduction in UCP4 and no alterations in UPC5. h Transcript expression analysis of SODs in the AMY. Higher SOD1 expression in control females than in control males is observed. Multiple comparisons: *P = 0.046. Bar plots with individual values represent means ± SD. n = 7 per sex from 7 litter per group.
