Fig. 5: Transcriptional analysis of mitochondria biogenesis in PFC and AMY of control and POL-exposed male and female offspring.
From: Prenatal immune activation in mice induces long-term alterations in brain mitochondrial function
a PGC-1α mRNA expression in the PFC. There is no alteration across groups. b Nrf2 mRNA expression in the PFC. There is no alteration across groups. c Pro-fusion: mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) mRNA expression in the PFC. Reduced expression in POL-exposed offspring mice. Multiple comparisons: Mfn1, *P = 0.044 and Mfn2, *P = 0.023. d Pro-fission: dynamin 1 (DRP1/Dnm1) and dynamin 2 (Dnm2) mRNA expression in the PFC. Reduced expression in POL-exposed offspring mice. Multiple comparisons: Dnm1, *P = 0.02 and Dnm2, *P = 0.02, **P = 0.002. e PGC-1α mRNA expression in the AMY. There is no alteration across groups. f Nrf2 mRNA expression in the AMY. There is no alteration across groups. g Pro-fusion: Mfn1 and Mfn2 mRNA expression in the AMY. There is no alteration across groups in Mfn1 but a reduction in Mfn2 in POL-exposed females. Multiple comparisons: *P = 0.01. h Pro-fission: Dnm1 and Dnm2 mRNA expression in the AMY. There is no alteration across groups. Bar plots with individual values represent means ± SD. n = 7 per sex from 7 litter per group.
