Table 1 Demographic characteristics, biomarker levels, and multidomain assessment results of older adults with major depressive disorders (MDD), subjective cognitive decline (SCD), or neither (NC).

From: Differential neuropsychiatric associations of plasma biomarkers in older adults with major depression and subjective cognitive decline

 

MDD (n = 23)

SCD (n = 23)

NC (n = 36)

p1

p2

A. Demographics

Age

66.91 ± 3.10

68.78 ± 6.07

67.17 ± 3.03

0.757

0.246

Sex (female)

19(82.6%)

10(43.5%)

22(61.1%)

0.080

0.185

Education

10.87 ± 2.17

10.91 ± 4.21

10.33 ± 3.44

0.554

0.565

B. Plasma biomarker

Aβ42 (pg/ml)

16.458 ± 0.555

16.286 ± 0.557

16.496 ± 0.454

0.772

0.119

Aβ40 (pg/ml)

51.228 ± 5.994

53.418 ± 5.598

51.700 ± 7.004

0.791

0.326

Tau (pg/ml)

22.324 ± 2.641

21.712 ± 2.933

22.569 ± 2.964

0.749

0.282

p-Tau181 (pg/ml)

3.738 ± 0.556

3.756 ± 0.545

4.006 ± 0.548

0.074

0.092

NfL (pg/ml)

9.642 ± 3.439

9.699 ± 2.902

9.590 ± 2.682

0.948

0.883

GFAP (pg/ml)

15.571 ± 4.661

17.415 ± 5.990

18.424 ± 7.042

0.106

0.586

Aβ42/Aβ40

0.326 ± 0.043

0.308 ± 0.035

0.325 ± 0.049

0.961

0.156

Tau/Aβ42

1.355 ± 0.143

1.334 ± 0.179

1.368 ± 0.176

0.770

0.472

p-Tau181/Aβ42

0.227 ± 0.032

0.231 ± 0.035

0.243 ± 0.033

0.075

0.186

C. Mental assessment

HADS-A

9.00 ± 4.05

5.65 ± 4.31

2.81 ± 2.70

<0.001*

0.003*

HADS-D

7.91 ± 4.03

5.22 ± 4.26

2.81 ± 2.74

<0.001*

0.021*

Ham-A

10.00 ± 7.04

3.04 ± 2.38

1.97 ± 2.16

<0.001*

0.079

Ham-D

9.45 ± 7.62

3.04 ± 2.99

1.78 ± 1.96

<0.001*

0.081

D. Cognition

AD8

3.13 ± 0.97

3.91 ± 1.95

0.17 ± 0.38

<0.001*

<0.001*

MoCA

25.52 ± 2.92

25.09 ± 3.41

26.03 ± 2.91

0.518

0.262

ADAS-cog

6.93 ± 3.25

7.29 ± 3.94

5.54 ± 3.84

0.156

0.096

DSST

54.59 ± 16.73

52.61 ± 18.73

56.11 ± 16.74

0.738

0.457

DST-f

12.36 ± 2.22

11.96 ± 2.80

11.92 ± 2.30

0.469

0.953

DST-b

6.77 ± 2.78

7.26 ± 2.78

6.08 ± 2.35

0.316

0.086

LNS

8.77 ± 1.77

8.65 ± 3.02

9.64 ± 2.49

0.159

0.177

CF-animal

16.00 ± 4.40

18.13 ± 4.36

19.56 ± 5.48

0.013*

0.297

CF-fruit

13.09 ± 3.50

12.78 ± 2.52

14.03 ± 3.33

0.313

0.131

CF-color

11.95 ± 2.87

12.35 ± 4.18

15.14 ± 3.77

0.001*

0.010*

CF-city

19.00 ± 5.92

22.74 ± 5.34

21.39 ± 6.56

0.168

0.412

FMT

36.68 ± 3.99

34.22 ± 4.23

36.25 ± 4.43

0.710

0.086

E. Physical activity

IPAQ-SF MET (minute per week)

3595 ± 2588

4896 ± 2315

3912 ± 2267

0.626

0.112

IPAQ-SF category

12,7,3

20,2,1

27,7,2

0.253

0.508

(high/median/low)

(54.5/31.8/13.6%)

(87.0/8.7/4.3%)

(75.0/19.4/5.6%)

 

F. Fatigue

PFS-physical

22.59 ± 8.38

17.00 ± 11.36

15.36 ± 10.10

0.011*

0.565

PFS-mental

21.05 ± 8.56

14.48 ± 11.47

11.64 ± 8.96

<0.001*

0.292

  1. p1, the p value for comparison between MDD and NC groups. p2, the p-value for comparison between SCD and NC groups. *Statistical significance at a p < 0.05.
  2. Aβ beta-amyloid, p-Tau181 phosphorylated Tau-181, NfL neurofilament light chain, GFAP glial fibrillary acidic protein, HADS-A hospital anxiety and depression scale-anxiety subscale, HADS-D HADS-depression subscale, Ham-A Hamilton anxiety rating scale, Ham-D Hamilton depression rating scale, MoCA Montreal cognitive assessment, ADAS-cog Alzheimer’s disease assessment scale-cognitive subscale, DSST digit symbol substitution test, DST-f forward digit span test, DST-b backward digit span test, LNS letter-number sequencing, CF category fluency. FMT facial memory test, IPAQ-SF International Physical Activity Questionnaire Short Form, MET metabolic equivalent, PFS Pittsburgh fatigability scale.
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