Fig. 1: Cortical thickness change across time.

a Significant reduction in cortical thickness from pre-treatment to on-treatment in the OUD group revealed by whole-brain paired t-test, thresholded at corrected p < 0.05. b Cortical thickness of the mPFC/aCC region of interest in the non-OUD group and the OUD group at the pre-treatment and on-treatment sessions. OUD opioid use disorder, mPFC medial prefrontal cortex, aCC anterior cingulate cortex.