Table 2 Plasma biomarker levels (pg/mL, mean ± SD): evening vs morning.
From: P-tau217 and other blood biomarkers of dementia: variation with time of day
Variable | Group | Time point | Mean | SD | ICC, (95% CI) |
|---|---|---|---|---|---|
P-tau217 (N = 21) | Total sample | p.m. | 0.767 | 0.676 | 0.93 (0.83, 0.97) |
a.m. | 0.653 | 0.519 | |||
Cognitively intact | p.m. | 0.348 | 0.129 | 0.94 (0.72, 0.99) | |
a.m. | 0.332 | 0.114 | |||
PLWA | p.m. | 1.323 | 0.810 | 0.86 (0.5, 0.97) | |
a.m. | 1.144 | 0.591 | |||
Study partner | p.m. | 0.515 | 0.269 | 0.95 (0.74, 0.99) | |
a.m. | 0.455 | 0.243 | |||
Aβ40 (N = 38) | Total sample | p.m. | 126.617 | 27.178 | 0.76 (0.58, 0.86) |
a.m. | 120.833 | 22.196 | |||
Cognitively intact | p.m. | 127.628 | 26.383 | 0.67 (0.38, 0.84) | |
a.m. | 121.050 | 22.276 | |||
PLWA | p.m. | 134.932 | 31.770 | 0.84 (0.44, 0.97) | |
a.m. | 129.656 | 20.061 | |||
Study partner | p.m. | 111.484 | 21.460 | 0.97 (0.82, 1) | |
a.m. | 109.710 | 22.910 | |||
Aβ42 (N = 38) | Total sample | p.m. | 7.898 | 1.907 | 0.88 (0.78, 0.93) |
a.m. | 7.722 | 1.667 | |||
Cognitively intact | p.m. | 7.914 | 2.106 | 0.87 (0.73, 0.94) | |
a.m. | 7.750 | 1.771 | |||
PLWA | p.m. | 8.475 | 1.643 | 0.89 (0.58, 0.98) | |
a.m. | 8.162 | 1.527 | |||
Study partner | p.m. | 7.062 | 1.171 | 0.88 (0.44, 0.98) | |
a.m. | 7.104 | 1.458 | |||
Aβ42/Aβ40 (N = 38) | Total sample | p.m. | 0.063 | 0.011 | 0.91 (0.83, 0.95) |
a.m. | 0.064 | 0.010 | |||
Cognitively intact | p.m. | 0.062 | 0.012 | 0.91 (0.8, 0.96) | |
a.m. | 0.064 | 0.011 | |||
PLWA | p.m. | 0.064 | 0.013 | 0.95 (0.78, 0.99) | |
a.m. | 0.063 | 0.010 | |||
Study partner | p.m. | 0.064 | 0.006 | 0.82 (0.25, 0.97) | |
a.m. | 0.065 | 0.007 | |||
GFAP (N = 38) | Total sample | p.m. | 148.756 | 77.933 | 0.83 (0.7, 0.91) |
a.m. | 145.723 | 65.281 | |||
Cognitively intact | p.m. | 134.118 | 61.617 | 0.87 (0.72, 0.94) | |
a.m. | 139.782 | 59.893 | |||
PLWA | p.m. | 204.898 | 99.056 | 0.69 (0.09, 0.93) | |
a.m. | 182.919 | 76.113 | |||
Study partner | p.m. | 132.451 | 85.748 | 0.95 (0.75, 0.99) | |
a.m. | 125.105 | 66.979 | |||
NfL (N = 38) | Total sample | p.m. | 22.500 | 9.626 | 0.93 (0.87, 0.96) |
a.m. | 23.344 | 9.679 | |||
Cognitively intact | p.m. | 21.072 | 6.597 | 0.84 (0.66, 0.93) | |
a.m. | 22.345 | 6.887 | |||
PLWA | p.m. | 27.439 | 7.881 | 0.87 (0.52, 0.97) | |
a.m. | 27.455 | 7.119 | |||
Study partner | p.m. | 21.629 | 18.676 | 0.99 (0.97, 1) | |
a.m. | 22.379 | 18.892 |
