Fig. 2: Cortical thinning with age across CN, CI, and CI-AD subjects. | Translational Psychiatry

Fig. 2: Cortical thinning with age across CN, CI, and CI-AD subjects.

From: Magnitude and kinetics of a set of neuroanatomic volume and thickness together with white matter hyperintensity is definitive of cognitive status and brain age

Fig. 2

A The t-map depicting the difference of entorhinal cortex thickness and parahippocampal gyrus thickness between CN vs CI, CN vs CI-AD, and CI vs CI-AD across early (CN = 300, CI = 29, and CI-AD = 58), intermediate (CN = 560, CI = 107, and CI-AD = 314), and late (CN = 222, CI = 61, and CI-AD = 216) (CN = 222, CI = 61, and CI-AD = 216) age groups. The significance was set to p < 0.017 (Bonferroni corrected) and the color bar depicts the t value. Higher the t value greater the difference between the thickness of cognitive groups. B, C The Boxplot with median (solid line) and mean (white square) thickness of the entorhinal cortex and parahippocampal gyrus stratified across the early, intermediate, and late age groups for CN (green), CI (blue), and CI-AD (red) subjects. P values were calculated using the unpaired, two-tailed Welch’s t test followed by Bonferroni correction. Statistical significance for the mean entorhinal cortex and parahippocampal gyrus thickness comparison among cognitive groups (CN, CI, and CI-AD) across the age groups is depicted as *p < 0.017, **p < 0.001. D, E LME regression model analysis of entorhinal cortex and parahippocampal gyrus thickness with age upon setting up the intercept at 50 years. Statistical significance for the slope and intercept comparison between CN vs CI (*), CN vs CI-AD (#), and CI vs CI-AD ($) was set at p < 0.05.

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