Fig. 4: White matter hyperintensity (WMH) loads across CN, CI, and CI-AD subjects. | Translational Psychiatry

Fig. 4: White matter hyperintensity (WMH) loads across CN, CI, and CI-AD subjects.

From: Magnitude and kinetics of a set of neuroanatomic volume and thickness together with white matter hyperintensity is definitive of cognitive status and brain age

Fig. 4

A Segmentation mask of WMH load generated from T1w, and T2-FLAIR MRI for CN CI and CI-AD subjects across early, intermediate, and late age groups. B The Boxplot depicts the median (solid line) and the mean (white square) WMH volume across 50–64 (early) (CN = 300, CI = 29, and CI-AD = 58), 65–79 (intermediate) (CN = 560, CI = 107, and CI-AD = 314), and ≥80 (late) (CN = 222, CI = 61, and CI-AD = 216) subjects. p values were calculated with the Mann-Whitney U test followed by Bonferroni correction. Statistical significance for the WMH comparison among cognitive groups (CN, CI, and CI-AD) across the age groups was depicted as *p < 0.017, **p < 0.001. C The exponential increase of total WMH load with age across CN (green), CI (blue), and CI-AD (red) subjects. The equation represents the rate of change of WMH load where, r is the rate constant and V0 is the initial WMH volume at 50 years of age. D Bar plot depicting mean ± standard deviation WMH rate fold change for CI and CI-AD subjects with respect to cognitively normal (CN) subjects in NACC cohort. E Bar plot depicting Average WMH rate fold change in CI and Dementia (DM) subjects with respect to CN subjects in ADNI cohort.

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