Fig. 2: Association of the patterns of exposure to adverse life events with development of incident CKD.

The hazard ratios obtained from Cox proportional hazard regression models are shown. Model 1 was adjusted for age, sex and ethnicity. Model 2 was adjusted for confounders in Model 1 and education level, income level, employment status, Townsend deprivation index, BMI categories, smoking status, alcohol consumption, diet habit, and physical activity. Model 3 was adjusted for confounders in Model 2 and history of hypertension, diabetes, depression, anxiety, substance misuse, and Charlson comorbidity index categories. Model 4 was adjusted for confounders in Model 3 (without ethnicity) and polygenic risk score for estimated glomerular filtration rate. * Analyses were conducted in the genetic analysis cohort with qualified GWAS data. HR hazard ratio, CI confidence interval.