Table 2 Mediation effect of mediators for the associations of the “child-to-adulthood exposure” pattern and chronic kidney disease.

From: The association between patterns of exposure to adverse life events and the risk of chronic kidney disease: a prospective cohort study of 140,997 individuals

Mediator

Total effect (TE)

Pure natural direct effect (PNDE)

Total natural indirect effect (TNIE)

Proportion mediated (PM)a

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Percent (95% CI)

P value

BMI

1.36 (1.12 to 1.63)

0.004

1.32 (1.08 to 1.59)

0.010

1.03 (1.02 to 1.04)

<0.001

11.45% (6.39% to 28.58%)

0.004

Smoking

1.36 (1.12 to 1.63)

0.009

1.32 (1.08 to 1.58)

0.005

1.03 (1.01 to 1.05)

0.007

9.79% (2.75% to 28.08%)

0.009

Diet

1.31 (1.08 to 1.58)

0.009

1.32 (1.08 to 1.59)

0.007

0.99 (0.99 to 1.00)

0.068

–2.77% (–10.87% to 3.70%)

0.077

Hypertension

1.34 (1.10 to 1.61)

0.004

1.32 (1.09 to 1.59)

0.005

1.01 (1.01 to 1.02)

<0.001

4.50% (2.22% to 15.68%)

0.005

Diabetes

1.32 (1.08 to 1.58)

0.009

1.32 (1.08 to 1.59)

0.008

1.00 (0.99 to 1.00)

0.416

–1.22% (–6.03% to 2.08%)

0.424

  1. All models were adjusted for age, sex, ethnicity, education level, employment status, Townsend deprivation index, BMI category, smoking status, diet habit, alcohol consumption, physical activity, history of hypertension, history of diabetes, history of depression, history of anxiety, history of substance misuse, and Charlson index categories, with exclusion of the mediator as appropriate in each model.
  2. HR hazard ratio, CI confidence interval.
  3. aProportion mediated as calculated by: PM = ×(TNIE-1)/(TE-1).
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