Fig. 1: Edaravone alleviated locomotor and cognitive impairments caused by chronic hypobaric hypoxia. | Translational Psychiatry

Fig. 1: Edaravone alleviated locomotor and cognitive impairments caused by chronic hypobaric hypoxia.

From: Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes

Fig. 1

A Study design: Eight- to nine-week-old C57BL/6 male mice were randomly allocated to the following groups: plain+vehicle, HA+vehicle, HA+treatment and HA+prevention. All mice underwent a battery of behavioural tests from Days 36–44 and were sacrificed on Day 45. B Changes in body weight from Day 0 to Day 35 in the plain+vehicle, HA+vehicle, HA+treatment and HA+prevention groups. C, D Representative trajectory diagrams (C) and total distance travelled (D) of mice in the open field test. E, F Representative heatmaps (E) and discrimination ratios (F) of mice in the plain+vehicle, HA+vehicle, HA+treatment and HA+prevention groups in the novel object recognition test. “N” and “F” represent “novel object” and “familiar object”, respectively. G–I Diagram of the Barnes maze (G) and latency to enter the target hole (H) and errors made (I) during the learning acquisition period. Data are presented as mean ± SEM. Statistical comparisons were performed by two-way (B, H, I) and one-way (D, F) ANOVA with Tukey’s post hoc test. N = 9/group. *P < 0.05, **P < 0.01, ***P < 0.001. HA, high altitude; NORT, novel object recognition test; OFT, open field test.

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