Fig. 5: Edaravone abrogated alterations in brain gene expression induced by hypobaric hypoxia. | Translational Psychiatry

Fig. 5: Edaravone abrogated alterations in brain gene expression induced by hypobaric hypoxia.

From: Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes

Fig. 5

A Hierarchical clustering heatmap of differentially expressed genes in the hippocampus of plain+vehicle, HA+vehicle, HA+treatment and HA+prevention mice. B Venn diagram of differentially expressed genes regulated by chronic hypobaric hypoxia and edaravone treatment and prevention. C–E Significantly enriched biological processes of the differentially expressed genes between the plain+vehicle and HA+vehicle groups (C), between the HA+treatment and HA+vehicle groups (D), and between the HA+prevention and HA+vehicle groups (E) analysed by Gene Ontology analysis. N = 3/group. HA, high altitude.

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