Table 3 Evaluated correlations between MADRS score and demographic, questionnaire, gene expression, and polysomnographic variables.

	Parameter		MADRS score
			R	p value
Demographics	Age		−0.032	0.719
Demographics	BMI		0.183	0.041
Questionnaires	ME score of CQ		0.332	<0.001
	AM score of CQ		0.557	<0.001
	ISI score		0.611	<0.001
	ESS score		0.175	0.047
Gene expression	Evening	BMAL1	−0.047	0.624
	Morning	BMAL1	0.247	0.011
	Evening	CLOCK	0.040	0.682
	Morning	CLOCK	0.259	0.009
	Evening	CRY1	−0.002	0.986
	Morning	CRY1	0.243	0.014
	Evening	PER1	−0.009	0.926
	Morning	PER1	0.293	0.003
	Evening	NPAS2	−0.076	0.412
	Morning	NPAS2	0.232	0.024
	Evening	NR1D1	−0.042	0.660
	Morning	NR1D1	0.249	0.010
PSG parameters	Sleep efficiency		−0.127	0.301
	Sleep onset latency		0.045	0.615
	Sleep maintenance efficiency		−0.144	0.243
	REM sleep latency		0.055	0.534
	TST		0.037	0.675
	REM		−0.024	0.793
	N1 nREM		0.126	0.157
	N2 nREM		−0.116	0.193
	N3 nREM		−0.021	0.813
	nREM		0.010	0.912
	Arousal index		0.125	0.160
	AHI		0.159	0.071
	AHI in REM		0.134	0.134
	AHI in nREM		0.184	0.039
	Total number of desaturations		0.166	0.172
	Desaturation index		0.179	0.041
	Basal SpO₂		−0.148	0.095
	Mean SpO₂ during desaturations		−0.138	0.118
	Minimum SpO₂		−0.107	0.256

AHI apnea-hypopnea index, AM subjective amplitude, BMAL1 brain and muscle ARNT-like 1, BMI body mass index, CLOCK circadian locomotor output cycles kaput, CRY1 cryptochrome 1, CQ Chronotype Questionnaire, ESS Epworth Sleepiness Scale, ISI Insomnia Severity Index, MADRS Montgomery-Åsberg Depression Rating Scale, ME morningness-eveningness, NPAS2 neuronal PAS domain 2, NR1D1 nuclear receptor subfamily 1 group D member 1, nREM non-rapid eye movement, OSA obstructive sleep apnea, PER1 period 1, REM rapid eye movement, SpO₂ oxygen saturation, TST total sleep time.
Bold values in the tables mark statistically significant data.

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