Fig. 3: Glutamate concentration in PrL at different stages of the addiction model and changes of the glutamate concentration across different stages, as well as their relationship with drug seeking behavior. | Translational Psychiatry

Fig. 3: Glutamate concentration in PrL at different stages of the addiction model and changes of the glutamate concentration across different stages, as well as their relationship with drug seeking behavior.

From: Glutamate concentration of medial prefrontal cortex is inversely associated with addictive behaviors: a translational study

Fig. 3

A The anatomic location of PrL where the MRS data were collected from. B Bar plots of glutamate concentration. The METH group exhibit significant lower level of concentration than the SAL group after the training periods. The error bar represents the standard error of mean. C Partial correlation between glutamate concentration (measured after the shock phase) and number of active lever pressing during the cue-reactivity sessions at abstinent day 3 or day 30. Each data point indicates a rat from the METH group. D Partial correlation between glutamate concentration change (concentration measured after the shock phase relative to that measured at baseline) and number of active lever pressing at abstinent day 3 or day 30. Each data point indicates a rat from the METH group. The pressing of inactive lever at the cue-reactivity session at abstinent day 3 was included as a covariate of confound in all partial correlations. **p < 0.01.

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