Fig. 2: Graph of genomic structural equation modeling (gSEM) results.

The blue circles, numbered from 1 to 32, represent the cortical surface area (SA) and cortical thickness (CT) of regions defined by the Desikan–Killiany atlas in the figure legend. Two separate gSEMs were carried out on A Latent SA variables, indicated by green circles, representing the genetic contributions from regional SA, which are specified by thick green lines and arrows. Thin green lines connect genetically related SA variables with their genetic correlation strength (rg) indicated in green boxes. B Latent CT variables, indicated by red circles, represent the genetic contributions from regional CT, which are specified by thick red lines and arrows. Thin red lines connect genetically related CT variables with their genetic correlation strength (rg) indicated in red boxes. SA surface area, CT cortical thickness, GIBN genetically informed brain network.