Fig. 5: Receptor density. | Translational Psychiatry

Fig. 5: Receptor density.

From: Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture

Fig. 5

Dice’s coefficients and corresponding p values between each of the 4 CT and 6 SA GIBNs and neuroreceptor density. The 20 receptors included serotonin 1a (5-HT1a), serotonin 1b (5-HT1b), serotonin 2a (5-HT2a), serotonin 4 (5-HT4), serotonin 6 (5-HT6), serotonin transporter (5-HTT), alpha-4 beta-2 nicotinic (α4β2), cannabinoid type 1 (CB1), dopamine D1 (D1), dopamine D2 (D2), dopamine transporter (DAT), fluorodopa (fDOPA), gamma aminobutyric acid A (GABAa), histamine type 3 (H3), muscarinic acetylcholine (M1), metabotropic glutamate receptor 5 (mGluR5), opioid (MOR), norepinephrine (NorEpi), N-methyl-D-aspartic acid (NMDA), vesicular acetylcholine transporter (VAchT). In Hansen et al. [43] and the 10 GIBNs maps were used to calculate Dice’s coefficient and corresponding FDR-corrected p values for A the highest 20% receptor density, and B the lowest 20% receptor density (* FDR-corrected p value < 0.05). The results, consisting of 200 Dice’s coefficients (20 receptors × 10 GIBNs), are displayed in heatmaps. SA surface area, CT cortical thickness, GIBN genetically informed brain network.

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