Fig. 1: Cell type taxonomy in control and BD basal ganglia. | Translational Psychiatry

Fig. 1: Cell type taxonomy in control and BD basal ganglia.

From: Exploring PDE5A upregulation in bipolar disorder: insights from single-nucleus RNA sequencing of human basal ganglia

Fig. 1

A, B Unbiased clustering and visualization of snRNA-seq data from control and BD basal ganglia using UMAP, respectively. Cell types were annotated according to expression of known marker genes. C, D Heatmap with scaling by column showed the relative number of predefined cell type markers overlapped with top 100 genes ranked by PEM scores for control and BD basal ganglia, respectively. E, F Markers and expression statistics used for defining cell types in control and BD basal ganglia, respectively. Micro, microglia; D1/D2-MSN-1/2, dopamine receptor D1/D2 containing medium spiny neuron subtype 1/2; DaN, dopaminergic neuron; InterN-1/2/3/4, interneuron subtype 1/2/3/4; Endo-1/2/3, endothelial subtype 1/2/3; Astro-1/2, astrocyte subtype 1/2; Oligo-1/2, oligodendrocyte subtype 1/2; OPC, oligodendrocyte precursor cell; Ependyl, ependymal cell.

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