Fig. 1: Experimental design and behavioral outcomes in the rCHI animal model.

A Schematic illustration of the rCHI model with a dashed box indicating the damaged area. B Diagram of the experimental design outlining the timeline and procedures. C Representative images from the three-chamber sociability test, accompanied by statistical analysis of interaction time. D Results from the grasping test, including grasping scores and drop latency measurements. E Statistical analysis of immobility time during the forced swim test. F Representative images from the open field test, along with statistical data online crossings and time spent in the center. G Representative images from the elevated plus maze and statistical analysis of entries and time spent in the open arms. Data are presented as mean ± SEM. *P < 0.05 versus Cont group, #P < 0.05 versus rCHI group. ns indicates no significant differences.