Table 2 Serotonin metabolism & cognitive function.

From: Psychiatric and cognitive function in patients with serotonin producing neuroendocrine tumors

Outcome	Predictors	Beta	SE beta	Standard beta	t-value	p-value	R²	SD (residual)	F-value	p-value
5-HT serum levels
Overall cognitive function	Constant	1.204	0.612		1.966	0.053	0.043	0.581	0.853	0.496
	5-HT	0.000	0.004	−0.011	−0.095	0.925
	Age	0.005	0.007	0.074	0.658	0.513
	Sex	0.101	0.130	0.088	0.782	0.437
	Education	−0.094	0.064	−0.166	−1.461	0.148
Memory function	Constant	0.267	0.932		0.286	0.776	0.021	0.884	0.406	0.803
	5-HT	−0.001	0.007	−0.010	−0.089	0.929
	Age	0.013	0.011	0.140	1.227	0.224
	Sex	0.067	0.197	0.039	0.342	0.734
	Education	−0.005	0.098	−0.006	−0.048	0.962
Attention	Constant	2.357	1.301		1.812	0.074	0.047	1.234	0.942	0.445
	5-HT	0.000	0.009	0.006	0.052	0.959
	Age	−0.004	0.015	−0.027	−0.241	0.810
	Sex	0.356	0.276	0.145	1.292	0.200
	Education	−0.191	0.137	−0.158	−1.397	0.166
Executive function	Constant	0.821	0.930		0.883	0.380	0.079	0.882	1.635	0.174
	5-HT	0.003	0.007	0.055	0.494	0.623
	Age	0.010	0.011	0.105	0.944	0.348
	Sex	−0.375	0.197	−0.211	−1.905	0.061
	Education	−0.100	0.098	−0.114	−1.028	0.307
TRP serum levels
Overall cognitive function	Constant	1.231	0.748		1.647	0.104	0.045	0.587	0.862	0.491
	TRP	−0.001	0.006	−0.020	−0.173	0.863
	Age	0.005	0.007	0.082	0.708	0.481
	Sex	0.089	0.135	0.077	0.662	0.510
	Education	−0.094	0.066	−0.165	−1.437	0.155
Memory function	Constant	1.357	1.117		1.215	0.228	0.051	0.877	0.997	0.415
	TRP	−0.013	0.009	−0.183	−1.570	0.121
	Age	0.011	0.011	0.114	0.998	0.321
	Sex	−0.026	0.202	−0.015	−0.129	0.898
	Education	−0.024	0.098	−0.028	−0.247	0.805
Attention	Constant	2.061	1.592		1.295	0.199	0.047	1.250	0.919	0.457
	TRP	0.003	0.012	0.033	0.283	0.778
	Age	−0.003	0.016	−0.019	−0.164	0.871
	Sex	0.376	0.288	0.151	1.305	0.196
	Education	−0.186	0.140	−0.152	−1.333	0.187
Executive function	Constant	0.454	1.120		0.406	0.686	0.102	0.880	2.101	0.089
	TRP	0.008	0.009	0.104	0.917	0.362
	Age	0.012	0.011	0.124	1.111	0.270
	Sex	−0.391	0.202	−0.218	−1.932	0.057
	Education	−0.121	0.098	−0.136	−1.228	0.223
5-HIAA serum levels^a
Overall cognitive function	Constant	1.205	0.713		1.689	0.095	0.044	0.587	0.859	0.493
	5-HIAA	−0.007	0.053	−0.015	−0.130	0.897
	Age	0.005	0.007	0.085	0.740	0.462
	Sex	0.092	0.133	0.079	0.690	0.493
	Education	−0.096	0.067	−0.167	−1.427	0.158
Memory function	Constant	0.194	1.082		0.179	0.858	0.021	0.890	0.402	0.806
	5-HIAA	0.030	0.081	0.044	0.365	0.716
	Age	0.012	0.011	0.131	1.123	0.265
	Sex	0.048	0.202	0.027	0.235	0.815
	Education	−0.011	0.102	−0.013	−0.109	0.913
Attention	Constant	2.960	1.512		1.958	0.054	0.056	1.244	1.102	0.362
	5-HIAA	−0.100	0.113	−0.103	−0.882	0.381
	Age	−0.002	0.016	−0.013	−0.118	0.906
	Sex	0.328	0.283	0.132	1.158	0.251
	Education	−0.214	0.142	−0.175	−1.505	0.137
Executive function	Constant	0.278	1.060		0.262	0.794	0.117	0.872	2.441	0.054
	5-HIAA	0.114	0.079	0.163	1.442	0.154
	Age	0.010	0.011	0.099	0.893	0.375
	Sex	−0.393	0.198	−0.218	−1.980	0.051
	Education	−0.093	0.100	−0.105	−0.936	0.352

5-HT 5-hydroxytryptamine, TRP tryptophan, 5-HIAA 5-hydroxyindoleacetic acid.
Significant p-values are highlighted in bold.
^aLog transformed.

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Table 2 Serotonin metabolism & cognitive function.

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