Fig. 1: Aripiprazole, but not raclopride, preserves the antidepressant effects of ketamine. | Translational Psychiatry

Fig. 1: Aripiprazole, but not raclopride, preserves the antidepressant effects of ketamine.

From: Fine-tuning of dopamine receptor signaling with aripiprazole counteracts ketamine’s dissociative action, but not its antidepressant effect

Fig. 1

a Inhibitory effect of raclopride on ketamine-induced hyperactivation (vehicle: n = 11 mice; raclopride 0.1 mg/kg: n = 8 mice; raclopride 0.2 mg/kg: n = 8 mice; raclopride 0.3 mg/kg: n = 3 mice; raclopride 1.0 mg/kg: n = 3 mice; Dunnett’s multiple comparisons test, ****P < 0.0001). b, c Total immobility time and the time course in the FST (vehicle: n = 18 mice; ketamine: n = 17 mice; raclopride 0.1 mg/kg plus ketamine: n = 18 mice; Dunnett’s multiple comparisons test, *P < 0.05 vs vehicle in (b). Two-way repeated-measures ANOVA followed by uncorrected Fisher’s LSD post hoc test, *P < 0.05 vs vehicle in (c)). d Suppressive effect of aripiprazole on normalized ketamine-induced locomotion (vehicle: n = 11; aripiprazole 0.1 mg/kg: n = 6; aripiprazole 0.3 mg/kg: n = 8; aripiprazole 1.0 mg/kg: n = 6; Dunnett’s multiple comparisons test, *P < 0.05, **P < 0.01). e, f Total immobility time and the time course in the FST 1 day after administration (vehicle: n = 24 mice; ketamine: n = 23 mice; aripiprazole 1.0 mg/kg plus ketamine: n = 24 mice; Dunnett’s multiple comparisons test, ***P < 0.001, **** P < 0.0001 vs vehicle in (e). Two-way repeated-measures ANOVA followed by uncorrected Fisher’s LSD post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs vehicle, # P < 0.05 vs ketamine in (f)).

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