Fig. 1: Distinct functional alterations in three MDD subtypes.

Brain charts display significantly differed brain regions in amplitude of low-frequency fluctuations (ALFF) in Subtype 1 A, Subtype 2 B, and Subtype 2 C compared to HC. The significance level was set to p < 0.05 (with Gaussian random field correction). L, left. R, right. The color bar represents the t-value. The elevated bar indicates a significant increase in ALFF of brain regions, and the lower bar indicates a significant decrease in ALFF in this subtype compared to HC. Red represents increased and blue decreased ALFF.