Table 2 Pretreatment demographics and clinical characteristics of study participants.

From: Lack of association between pretreatment glutamate/GABA and major depressive disorder treatment response

Characteristics

Remitters (N = 25)

Non-remitters (N = 48)

p-value1

Responders (N = 51)

Non-responders (N = 23)

p-value1

Age, years, mean (SD)

30.4 (15.7)

29.3 (12.7)

0.74

30.4 (14.5)

28.2 (11.5)

0.52

Range

18–64

18–65

 

18–65

19–60

 

Sex, N (%)

  

0.43

  

0.28

Male

10 (40)

14 (29.2)

 

19 (37.3)

5 (21.7)

 

Female

15 (60)

34 (70.8)

 

32 (62.7)

18 (78.3)

 

Race/Ethnicity

  

0.13

  

0.72

Caucasian

15

30

 

33

13

 

African

American

2

2

 

2

2

 

Asian

2

12

 

8

6

 

Pacific Islander

1

0

 

1

0

 

Mixed

5

4

 

7

2

 

17-item Hamilton Depression Rating Scale, mean (SD)

15.9 (3.9)

18.8 (4.9)

0.01

17.5 (4.3)

18.3 (5.6)

0.50

Days of treatments, mean (SD)

58.7 (7.3)

59.5 (8.2)

0.46

59.0 (9.1)

58.5 (6.6)

0.28

Subtype of depression, N (%)

  

0.21

  

0.18

Atypical

6 (24)

4 (8.3)

 

9 (17.6)

2 (8.70)

 

Melancholic

6 (24)

13 (27.1)

 

10 (19.6)

9 (39.1)

 

No subtype

13 (52)

31 (64.6)

 

32 (62.7)

12 (52.2)

 

DSM-IV comorbidity at time of study, N (%, n=number of unknowns)

 None

4 (17.4, unk = 2)

6 (13.0, unk = 2)

 

8 (16.3, unk = 2)

3 (14.3, unk = 2)

 

 OCD

0 (0)

2 (4.2)

 

1 (1.96)

1 (4.35)

 

 PTSD

2 (8.7, unk = 2)

13 (28.3, unk = 2)

 

10 (20.4, unk = 2)

5 (23.8, unk = 2)

 

 Alcohol Abuse

5 (20.0)

8 (16.7)

 

10 (19.6)

3 (13.0)

 

 Cannabis Abuse

6 (25.0, unk = 1)

6 (12.5)

 

8 (16.0, unk = 1)

4 (17.4)

 

 Any Other Anxiety Disorder

17 (73.9, unk = 2)

40 (83.3)

 

37 (75.5, unk = 2)

20 (87.0)

 

 Number of antidepressant trials, lifetime, N (%, n = unknowns)

  

0.50

  

0.69

 None

15 (62.5, unk = 1)

24 (52.2, unk = 2)

 

26 (54.2, unk = 3)

13 (56.5)

 

 1

4 (16.7, unk1)

7 (15.2, unk = 2)

 

8 (16.7, unk = 3)

3 (13.00)

 

 ≥2

5 (20.8, unk = 1)

15 (32.6, unk = 2)

 

14 (29.2, unk = 3)

7 (30.4)

 
  1. In parentheses are standard deviation (SD) or percentage of each variable, calculated as number of occurrence/totals with known data. ukn = number of participants for which this variable is not recorded, which is 0 unless specified.
  2. 1For categorical variables, p-value was based on a Chi-squared test with exact p-value from Monte Carlo simulation; for continuous variables, p-value was based on a t test.
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