Fig. 2: Aberrant synaptic potentiation in male CaMKIIα P212L Ht mice. | Translational Psychiatry

Fig. 2: Aberrant synaptic potentiation in male CaMKIIα P212L Ht mice.

From: A hyper-activatable CAMK2A variant associated with intellectual disability causes exaggerated long-term potentiation and learning impairments

Fig. 2

A Summary plot of normalized fEPSP slope measurements. Following 20 min of baseline recording, 10 Hz 90 s stimulation was applied. Inset: Sample traces of fEPSPs recorded with hippocampal slices from WT (upper panel) and Ht (lower panel) mice. B Plots of normalized fEPSP slope averaged from 35–40 min after 10 Hz stimulation (unpaired Student’s t-test). Male: WT; n = 14, Ht; n = 9. Female: WT; n = 6, Ht; n = 8. C The paired-pulse ratio of WT and P212L Ht mice at 50, 100, and 200 ms intervals are plotted (two-way repeated measures ANOVA test). Inset: sample traces of fEPSPs recorded in WT (upper panel) and Ht (lower panel) mice. Male: WT; n = 8, Ht; n = 13, Female: WT; n = 9, Ht; n = 7. Data represents mean ± SEM. *p < 0.05.

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