Fig. 1: No major effect of mental health diagnosis (schizophrenia, bipolar disorder, healthy control) as a covariate in regression model on significance of PE class for the DG-SYM test in lipid class-based enrichment analysis in lipidR.

Distribution of log fold change (logFC) per lipid class, with significantly enriched classes (marked in red) for mean-based low (as seen in the plots) versus high results in the dataset including all individuals with schizophrenia, bipolar disorder, and healthy controls (sample size: 531 individuals). PE: phosphatidylethanolamine; DG-SYM: Digit-Symbol test.