Fig. 4: Environmental enrichment reversed the deleterious effects on hippocampus-dependent cognitive function in adult offspring induced by gestational aripiprazole exposure. | Translational Psychiatry

Fig. 4: Environmental enrichment reversed the deleterious effects on hippocampus-dependent cognitive function in adult offspring induced by gestational aripiprazole exposure.

From: Environmental enrichment improves deficits in hippocampal neuroplasticity and cognition in prenatally aripiprazole-exposed mouse offspring

Fig. 4

A Experimental timeline of prenatal aripiprazole administration, EE, behavioral assessment, Golgi-Cox staining, and immunohistochemistry procedures. B Heatmap of exploration time in the spatial object recognition (SOR) test. C Comparison of the percentage of time spent exploring objects in each group of mice in the SOR test. D EE ameliorated aripiprazole-induced deficits in spatial memory. E, F EE had no effect on anxiety-related behavior, as measured by the OF test and EPM. G Representative sections showing the immunoreactivity of DARPP-32 in the hippocampus of the four groups. Scale bar = 200 µm. H Aripiprazole administration prenatally decreased the expression of DARPP-32, whereas EE increased the expression level of DARPP-32. **P < 0.01, ***P < 0.001, comparisons between two groups; ##P < 0.01, ###P < 0.001, within-group comparisons; @P < 0.05, significant aripiprazole effect; &P < 0.05, significant intervention effect. SE standard environment, EE environmental enrichment.

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