Fig. 2: Association of lifestyle behaviors and their changes with the incidence of cognitive impairment.

A Histogram showing participant counts across the range of risk score of lifestyle behaviors for cognition (RSLC). Non-linear relationships between RSLC and incidence of cognitive impairment. Data were HR (solid line) and 95%CI (shadow area) from cox regression analysis with restricted cubic splines. The RCSs illustrated a U-shaped correlation between either a lower or higher baseline RSLC score and an increased risk of cognitive impairment. Conversely, upslope correlation lines were evident at follow-up. B Kaplan-Meier survival curves showing the overall survival according to the change trend of risk level of lifestyle behaviors for cognition. C Heatmap showing the HRs (see eTable 6) of incident cognitive impairment in different RLLC changes.