Fig. 2: Differential expression patterns across the nucleus accumbens (N), caudate (C), and putamen (P) in subjects with psychosis.

A Table of the number of transcripts that meet the criteria of being differentially expressed between two regions based on a cutoff of a main effect of brain region (q < 0.05), two-region comparison post-hoc q < 0.05, and a log2 fold change < −0.58 or > 0.58 (fold change ± 1.5 or 50% expression change). B Table of the number of transcripts that follow certain expression patterns based on a q-value and log2 fold change. For the top two patterns, transcripts are considered differentially expressed if they meet a cutoff of a main effect of brain region (q < 0.05), two-region comparison post-hoc q < 0.05, and a log2 fold change < −0.58 or > 0.58. For the following five expression patterns (hierarchy in expression across the three striatal subregions), transcripts are considered differentially expressed if they meet a cutoff of a main effect of brain region (q < 0.05), two-region comparison post-hoc q < 0.05, and a log2 fold change < −0.26 or > 0.26 (fold change ± 1.2 or 20% expression change). C Heat maps for two of the expression patterns in which the input is the list of genes corresponding to the N > (C = P) or N < (C = P) patterns. D Representative scatterplots of the expression of two transcripts. The scatterplot on the left follows a N > (C = P) pattern and the one on the right represents a N < (C = P) pattern. E Heatmaps of GO Biological Process enrichment using the web-based portal Metascape for the unique NAc enrichment (left) and expression patterns (right).