Fig. 4: Gain and loss of sex differences in psychosis.

A Table of the number of transcripts that lost or gained a sex difference in psychosis, separated by striatal subregion. For transcripts that lost a sex difference, M > F (unaffected) are the transcripts that had higher expression in male compared to female unaffected subjects, but no significant change in psychosis subjects. F > M (unaffected) conversely are those transcripts that had a higher expression in females compared to males in unaffected subjects, but no significant changes in psychosis subjects. For transcripts that gain a sex difference in psychosis and are in the M > F (psychosis) column, they did not have a sex difference in unaffected subjects but had a higher expression in male compared to female psychosis subjects. The same is true of female subjects with psychosis in the F > M (psychosis) category. B Circos plots representing the overlap of transcripts (purple) or pathways (blue) between the list of transcripts derived from the table in part (A). C GO Biological Process enrichment from the genes in Table (A) for loss (top) or gain (bottom) of sex differences. D RRHO plots that map the overlap between two lists of transcripts ranked by their p-values and effect size (with warmer colors indicating a high degree of overlap). Each quadrant visualizes the overlap between different sets of transcripts in the NAc (left), caudate (middle), or putamen (right). In the RRHO interpretation legend, the arrows refer to changes in male control or psychosis subjects.