Table 2 Associations of Phenotypic age acceleration with the odds of suicide attempt and suicidal ideation.

From: Associations of clinical biomarker-based biological aging with suicide attempts and suicidal ideation: evidence from 124,529 UK Biobank participants

Phenotypic age acceleration

 

Odds of suicide attempt

Cases (%)

Model 1

Model 2

Model 3

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Per SD increment

2718 (2.2)

1.128 (1.099–1.156)

<0.001

1.064 (1.026–1.103)

<0.001

1.051 (1.013–1.091)

0.009

Quartile 1

579 (1.9)

1(Reference)

 

1(Reference)

 

1(Reference)

 

Quartile 2

639 (2.1)

1.142 (1.018–1.280)

0.023

1.097 (0.978–1.230)

0.115

1.110 (0.989–1.246)

0.077

Quartile 3

637 (2.1)

1.151 (1.026–1.291)

0.017

1.057 (0.941–1.187)

0.349

1.055 (0.939–1.186)

0.368

Quartile 4

864 (2.8)

1.508 (1.353–1.681)

<0.001

1.244 (1.111–1.393)

<0.001

1.218 (1.087–1.366)

<0.001

P for trend

 

<0.001

<0.001

<0.001

Biologically youngera

1475 (2.0)

1(Reference)

 

1(Reference)

 

1(Reference)

 

Biologically older

1243 (2.5)

1.283 (1.187–1.387)

<0.001

1.123 (1.037–1.217)

0.005

1.104 (1.018–1.198)

0.017

Phenotypic age acceleration

Cases (%)

Odds of suicidal ideation

Per SD increment

5207 (4.2)

1.127 (1.099–1.156)

<0.001

1.062 (1.033–1.091)

<0.001

1.051 (1.022–1.080)

<0.001

Quartile 1

1092 (3.5)

1(Reference)

 

1(Reference)

 

1(Reference)

 

Quartile 2

1210 (3.9)

1.068 (0.982–1.162)

0.123

1.029 (0.946–1.220)

0.505

1.034 (0.950–1.126)

0.436

Quartile 3

1285 (4.1)

1.119 (1.029–1.216)

0.008

1.036 (0.953–1.127)

0.405

1.035 (0.951–1.126)

0.429

Quartile 4

1620 (5.2)

1.361 (1.256–1.474)

<0.001

1.148 (1.057–1.247)

<0.001

1.125 (1.035–1.224)

0.006

P for trend

 

<0.001

<0.001

<0.001

Biologically youngera

2833 (3.8)

1(Reference)

 

1(Reference)

 

1(Reference)

 

Biologically older

2374 (4.8)

1.210 (1.144–1.281)

<0.001

1.079 (1.017–1.144)

0.011

1.064 (1.003–1.129)

0.040

  1. OR odds ratio, CI confidence interval.
  2. aBiologically older and younger respectively represent Phenotypic age acceleration >0 and <0.
  3. Model 1 adjusted for age, sex, education, ethnicity, employment, and Townsend Deprivation Index.
  4. Model 2 adjusted for Model 1 plus smoking, alcohol consumption, physical activity, sleep duration, and body mass index.
  5. Model 3 adjusted for Model 2 plus hypertension, diabetes, coronary heart disease, stroke, and psychiatric disorders.
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