Fig. 1: SMIR Mice Develop Contextual Fear extinction dysfunction. | Translational Psychiatry

Fig. 1: SMIR Mice Develop Contextual Fear extinction dysfunction.

From: Chronic postoperative pain induces contextual fear extinction dysfunction through hippocampal NMDAR/BDNF/TrkB signaling pathway in mice

Fig. 1

A Experimental Flow Chart. B Mechanical allodynia was observed with PWT (n = 6). Differences between groups were adopted two-way RM (Repeated-measures) ANOVA followed by Tukey’s multiple comparisons test. ***p < 0.001, ****p < 0.0001 vs Control; ###p < 0.001, ####p < 0.0001 vs Sham. C Contextual Fear Conditioning Experiment (n = 12). Differences between groups were adopted two-way RM (Repeated-measures) ANOVA followed by Tukey’s multiple comparisons test. D Contextual Fear Extinction Experiment (n = 12). Differences between groups were adopted two-way RM (Repeated-measures) ANOVA followed by Tukey’s multiple comparisons test. E Contextual Fear Retrieval Experiment (n = 12). Differences between groups were adopted one-way ANOVA followed by Tukey’s multiple comparisons test. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.

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