Fig. 3: The BDNF/TrkB and NMDARs/ERK/CREB Signaling Pathways were Inhibited in SMIR Mice. | Translational Psychiatry

Fig. 3: The BDNF/TrkB and NMDARs/ERK/CREB Signaling Pathways were Inhibited in SMIR Mice.

From: Chronic postoperative pain induces contextual fear extinction dysfunction through hippocampal NMDAR/BDNF/TrkB signaling pathway in mice

Fig. 3

A Representative Western blot analysis of NR2B、NR2A、P-ERK、ERK、P-CREB and CREB in hippocampus. β-Tublin was included as loading control. B Quantitative analysis of NR2B levels (n = 4). C Quantitative analysis of NR2A levels (n = 4). D Quantitative analysis of P-Erk1/2 levels (n = 4). E Quantitative analysis of P-CREB levels (n = 4). F Representative Western blot analysis of PSD-95 in hippocampus. β-Tublin was included as loading Control. G Quantitative analysis of PSD-95 levels (n = 4). H Experimental flow chart. I Representative map of dendritic spine density of neurons in hippocampus. J Quantitative statistics of dendritic spine density (n = 6). Data are presented as the mean ± SEM. *p < 0.05, **p < 0.01.

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