Fig. 4: NMDARs Agonist Upregulates the Expression of BDNF through NMDARs/ERK/CREB Signaling Pathway. | Translational Psychiatry

Fig. 4: NMDARs Agonist Upregulates the Expression of BDNF through NMDARs/ERK/CREB Signaling Pathway.

From: Chronic postoperative pain induces contextual fear extinction dysfunction through hippocampal NMDAR/BDNF/TrkB signaling pathway in mice

Fig. 4

A Representative Western blot analysis of hippocampal BDNF and TrkB-fl (TrkB-full-length) after NMDA treatment. β-Tubulin was included as a loading Control. B Quantitative analysis of BDNF levels (n = 4). C Quantitative analysis of TrkB-fl (TrkB-full-length) levels (n = 4). D Representative Western blot analysis of hippocampal P-Erk1/2 and P-CREB after NMDA treatment. Erk1/2 and CREB were included as loading Control. E Quantitative analysis of P-Erk1/2 levels (n = 4). F Quantitative analysis of P-CREB levels (n = 4). G Quantitative analysis of mRNA levels of hippocampus BDNF gene after NMDA treatment (n = 4). H Experimental flow chart. Data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001.

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