Fig. 5: NMDARs Agonist Improves Contextual Fear extinction dysfunction in SMIR Mice by Inducing PSD-95 Expression and Increasing Dendritic Spines in the Hippocampus. | Translational Psychiatry

Fig. 5: NMDARs Agonist Improves Contextual Fear extinction dysfunction in SMIR Mice by Inducing PSD-95 Expression and Increasing Dendritic Spines in the Hippocampus.

From: Chronic postoperative pain induces contextual fear extinction dysfunction through hippocampal NMDAR/BDNF/TrkB signaling pathway in mice

Fig. 5

A Experimental flow chart. B Contextual Fear Conditioning Experiment (n = 11). Differences between groups were adopted two-way RM (Repeated-measures) ANOVA followed by Tukey’s multiple comparisons test. C Contextual Fear Extinction Experiment (n = 11). Differences between groups were adopted two-way RM (Repeated-measures) ANOVA followed by Tukey’s multiple comparisons test. D Contextual Fear Retrieval Experiment (n = 11). Differences between groups were adopted one-way ANOVA followed by Tukey’s multiple comparisons test. E Representative Western blot analysis of hippocampal PSD-95 after NMDA treatment. β-Tubulin was included as a loading Control. F Quantitative analysis of PSD-95 levels (n = 5). G Quantitative statistics of dendritic spine density (n = 6). H Representative map of dendritic spine density of neurons in hippocampus. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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