Fig. 6: TrkB Receptor Inhibitor (ANA-12) Reverses NMDA-ameliorated Contextual Fear extinction dysfunction in SMIR Mice by Inducing Hippocampal Dendritic Spine Loss. | Translational Psychiatry

Fig. 6: TrkB Receptor Inhibitor (ANA-12) Reverses NMDA-ameliorated Contextual Fear extinction dysfunction in SMIR Mice by Inducing Hippocampal Dendritic Spine Loss.

From: Chronic postoperative pain induces contextual fear extinction dysfunction through hippocampal NMDAR/BDNF/TrkB signaling pathway in mice

Fig. 6

A Experimental flow chart. B Contextual Fear Conditioning Experiment (n = 11). Differences between groups were adopted two-way RM (Repeated-measures) ANOVA followed by Tukey’s multiple comparisons test. C Contextual Fear Extinction Experiment (n = 11). Differences between groups were adopted two-way RM (Repeated-measures) ANOVA followed by Tukey’s multiple comparisons test. D Contextual Fear Retrieval Experiment (n = 11). Differences between groups were adopted one-way ANOVA followed by Tukey’s multiple comparisons test. E Representative map of dendritic spine density of neurons in hippocampus. F Quantitative statistics of dendritic spine density (n = 9). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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