Fig. 2: Overview of intersection points between bipolar disorder and ferroptosis.
From: Ferroptosis as a potential molecular mechanism of bipolar disorder
Our hypothesis of ferroptosis being implicated in the pathogenesis of bipolar disorder (BD) is supported by 1-Ferroptosis being involved in the pathogenesis of some of BD comorbidities, including Schizophrenia (SCZ), autism spectrum disorder (ASD), major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and alcohol use disorder (AUD). 2-The existence of ferroptosis hallmarks in BD. 3- Hypothalamic-adrenal axis disturbance in BD pathogenesis, which could induce ferroptosis. 4- Circadian rhythm disturbance in BD, which is echoed by the ferroptosis-induced degradation of circadian rhythm transcriptional factors (clockophagy). 5- Drugs used in BD treatment have antiferroptosis effect in other contexts.
