Table 5 Whole-brain analysis for group differences in the mean Focus-on-Breath vs. Describe contrast during neurofeedback runs (NF-1, NF-2, NF-3).

From: Posterior cingulate cortex downregulation training using fMRI neurofeedback in adolescents with early life adversity exposure: a randomized, single-blind trial

Hemisphere/location

Peak coordinates in MNI

t

Volume (mm3)

ELA-NF vs HC-NF

 R Superior Temporal Gyrus

67

−25

17

3.03

430

 L Calcarine Gyrus

1

−59

9

3.35

297

 L Middle Temporal Gyrus

−51

−61

19

4.03

274

 R Postcentral Gyrus

45

−27

41

4.62

265

 L Postcentral Gyrus

−43

−37

69

3.65

227

 R Fusiform Gyrus

31

−59

−17

3.37

214

 L Middle Temporal Gyrus

−51

−47

7

3.74

204

 L Paracentral Lobule

−1

−29

79

3.13

199

 L Superior Temporal Gyrus

−61

−19

13

3.59

148

 R Superior Parietal Lobule

29

−57

61

3.2

124

 L Precuneus

−5

−51

75

3.02

122

 L Superior Medial Gyrus

−1

41

53

3.21

120

 L Superior Temporal Gyrus

−39

−23

1

3.6

98

 L Precentral Gyrus

−41

3

55

3.03

92

 R Cerebellum (Crus 1)

47

−65

−23

3.11

89

 L Putamen

−27

−9

5

3.72

75

 L Inferior Temporal Gyrus

−59

−69

−9

3.27

72

 L Posterior Cingulate Cortex

−3

−41

5

3.27

69

 L Caudate Nucleus

−13

−13

23

3.12

69

 R Inferior Temporal Gyrus

65

−57

−9

3.85

66

 L SupraMarginal Gyrus

−67

−53

25

–2.9

66

 R Cerebellum (IV-V)

19

−37

−25

2.85

64

 L ParaHippocampal Gyrus

−15

−33

−9

3.92

64

 R Middle Temporal Gyrus

67

−19

−19

3.96

63

 L Precentral Gyrus

−45

9

47

2.89

63

 R Fusiform Gyrus

31

−39

−15

3.54

57

 L Postcentral Gyrus

−57

−17

41

3.15

56

ELA-NF vs ELA-SHAM

 R Precuneus

7

−83

47

3.16

935

 R Lingual Gyrus

21

−69

−11

3.13

389

 L Fusiform Gyrus

−27

−61

−9

4.22

389

 R Middle Frontal Gyrus

53

19

41

3.89

278

 R Inferior Parietal Lobule

45

−51

57

3.04

217

 Brain Stem

13

−23

−33

3.21

189

 R Postcentral Gyrus

47

−29

43

3.68

178

 R Precuneus

9

−51

37

3.04

170

 L Superior Medial Gyrus

−1

57

17

−3.25

150

 L Inferior Parietal Lobule

−35

−51

51

3.38

146

 R Middle Temporal Gyrus

69

−23

−17

3.37

138

 L Middle Frontal Gyrus

−29

37

27

–3.37

138

 R Middle Temporal Gyrus

45

−55

9

2.96

121

 L Middle Temporal Gyrus

−49

−71

17

2.92

86

 R Lingual Gyrus

1

−69

1

2.97

65

 L SupraMarginal Gyrus

−63

−23

45

2.91

57

 Left Cerebellum (Crus 2)

−7

−85

−27

3.34

56

  1. HC vs ELA (top) and NF vs SHAM (Bottom). The x, y, z coordinates indicate distance in millimeters from the anterior commissure in three dimensions: x, right to left; y, anterior to posterior; z, dorsal to ventral with positive values indicating right, anterior or dorsal and negative values left, posterior or ventral, respectively. The number of voxels in each cluster reflects contiguous voxels in which p < 0.000001 after applying appropriate corrections for multiple comparisons. All coordinates reported according to MNI space.
  2. L left, NF neurofeedback run, R right, HC healthy control, ELA early life adversity.