Fig. 3: The associations of CSF PGRN and sTREM2 with amyloid pathology. | Translational Psychiatry

Fig. 3: The associations of CSF PGRN and sTREM2 with amyloid pathology.

From: Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Fig. 3

CSF PGRN was associated with higher levels of CSF Aβ1–42 A. CSF sTREM2 was associated with higher levels of CSF Aβ1–42 B. PGRN could increase CSF Aβ1–42 partially by modulating CSF sTREM2. Mediation analyses revealed that CSF PGRN could increase CSF Aβ1–42 partially by modulating CSF sTREM2, and CSF sTREM2 could also modulate the relationship between CSF PGRN and CSF Aβ1–42 C. The CABLE data are depicted in blue and ADNI data in red. CSF cerebrospinal fluid.

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