Table 1 Characteristics of participants.
CABLE (N = 905) | ADNI (N = 973) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cognitively normal | CDR = 0 | CDR = 0.5 | CDR = 1 | |||||||||||||
A-/TN- (316) | A+/TN- (274) | A+/TN+ (101) | A-/TN+ (214) | A-/TN- (121) | A+/TN- (52) | A+/TN+ (45) | A-/TN+ (73) | A-/TN- (119) | A+/TN- (90) | A+/TN+ (274) | A-/TN+ (97) | A-/TN- (2) | A+/TN- (12) | A+/TN+ (80) | A-/TN+ (8) | |
Age | 61.1 (9.9) | 60.1 (10.7) | 64.4 (11.1) | 65.5 (9.9) | 72.5 (5.4) | 73.2 (6.1) | 76.5 (5.5) | 74.5 (6.6) | 69.7 (7.6) | 72.6 (7.7) | 73.3 (7.1) | 73.2 (8.1) | 89.2 (1.6) | 77.9 (3.7) | 73.9 (9.2) | 80.0 (7.4) |
Female, n (%) | 113 (35.8) | 117 (42.7) | 52 (51.5) | 82 (38.3) | 58 (47.9) | 52 (46.1) | 23 (51.1) | 41 (56.2) | 54 (45.4) | 20 (22.2) | 117 (42.7) | 43 (44.3) | 0 (0) | 4 (33.3) | 40 (50.0) | 2 (25) |
APOE4 carriers, n (%) | 36 (11.4) | 54 (19.7) | 19 (18.8) | 30 (14.1) | 16 (13.2) | 22 (42.3) | 26 (57.8) | 16 (21.9) | 25 (21.2) | 43 (47.8) | 208 (75.9) | 32 (33) | 0 (0) | 6 (50) | 59 (73.8) | 1 (12.5) |
Education, y | 10.0 (4.4) | 9.8 (4.2) | 9.4 (4.4) | 9.7 (4.1) | 16.3 (2.8) | 16.4 (2.8) | 16.6 (2.5) | 16.4 (2.5) | 16.1 (2.7) | 16.1 (3.0) | 15.8 (2.9) | 15.9 (2.7) | 17.0 (0.0) | 16.1 (2.8) | 15.2 (2.8) | 14.9 (2.0) |
CSF measurements, mean (SD), pg/ml | ||||||||||||||||
PGRN | 1685 (178) | 1612 (202) | 1655 (205) | 1733 (180) | 1500 (291) | 1424 (358) | 1572 (307) | 1756 (357) | 1561 (405) | 1556 (927) | 1565 (435) | 1700 (328) | 1885 (490) | 1726 (403) | 1707 (614) | 1974 (475) |
sTREM2 | 19,015 (6271) | 15,254 (7116) | 18,686 (6996) | 20,424 (5884) | 3698 (1733) | 2830 (1661) | 4866 (2218) | 5353 (2141) | 3404 (1752) | 2735 (1298) | 4439 (2374) | 5172 (2293) | 5660 (2008) | 3009 (1003) | 3907 (2014) | 7406 (3331) |
Aβ1–42 | 206.5 (86.4) | 107.6 (10.1) | 107.7 (10.3) | 261.9 (164.9) | 1515 (305) | 731 (198) | 723 (163) | 1923 (623) | 1525 (391) | 648 (195) | 636 (166) | 1642 (551) | 1330 (15) | 565 (193) | 579 (157) | 1804 (715) |
P-tau181 | 33.7 (5.0) | 32.8 (5.1) | 49.0 (13.4) | 48.3 (13.7) | 16.2 (2.9) | 15.5 (3.9) | 33.3 (9.0) | 29.0 (7.4) | 15.8 (3.3) | 15.9 (4.2) | 38.8 (13.8) | 30.9 (12.0) | 19.3 (1.2) | 18.5 (2.1) | 39.2 (15.1) | 41.3 (21.9) |
T-tau | 153.1 (36.1) | 132.7 (34.8) | 254.5 (149.6) | 260.2 (122.3) | 184.4 (32.3) | 168.4 (38.6) | 332.0 (78.5) | 323.9 (72.7) | 184.1 (37.4) | 172.2 (40.3) | 378.6 (124.3) | 332.5 (97.8) | 233.7 (6.1) | 199.3 (21.7) | 393.7 (137.1) | 467.9 (213.1) |
