Fig. 4: Tsc2+/− mice exhibited altered structural connectivity involving the cortex-amygdala-hippocampus circuit in a sex-dependent matter. | Translational Psychiatry

Fig. 4: Tsc2+/− mice exhibited altered structural connectivity involving the cortex-amygdala-hippocampus circuit in a sex-dependent matter.

From: Sex-specific cortical networks drive social behavior differences in an autism spectrum disorder model

Fig. 4

A Representative ROI masks for the whole cortex (purple), amygdala (yellow) and hippocampus (green) and a schematic diagram of the cortex-amygdala-hippocampus circuit. B Representative images for both WT and Tsc2+/− mice of FA color maps, ADC images, and fiber tracts from the sex with the most reported alterations. Structural connectivity measures included C FA and D ADC values and E the number of fiber tracts within the cortex-amygdala-hippocampus circuit. The results are expressed as mean ± SEM (n = 10–14 for each group). *p < 0.05 by 2WAY ANOVA with Sidak’s multiple comparisons test. ADC Apparent diffusion coefficient, AMY Amygdala, FA Fractional anisotropy, HIPPO Hippocampus, ROI Region of interest.

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